TB-500 is a synthetic peptide corresponding to the 43-amino acid sequence of Thymosin Beta-4 (Tβ4), an endogenous actin-sequestering protein involved in the regulation of cytoskeletal dynamics, cell motility, and extracellular matrix remodeling. Thymosin beta-4 is present in virtually all nucleated mammalian cells and plays a central role in controlling the availability of monomeric actin for polymerization.

In preclinical experimental systems, TB-500 is utilized to investigate actin-associated cell migration, endothelial cell proliferation, angiogenic signaling, and wound repair biology. Researchers employ the peptide in in-vitro migration assays, tube formation studies, and in-vivo animal models examining extracellular matrix remodeling and extracellular matrix reorganization.

Published preclinical literature describes TB-500 in studies of cardiac cellular signaling, neural signaling markers, musculoskeletal repair pathways, and dermal wound closure dynamics. The peptide’s actin-binding domain (LKKTETQ motif) is considered the primary active region for cell motility-associated effects observed in experimental systems.

Sequence: Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S Molecular Weight: 4963.44 g/mol CAS: 77591-33-4

Supplied exclusively for controlled laboratory research. Not for human consumption.