Kisspeptin-10 is a synthetic C-terminal decapeptide derived from the full-length kisspeptin-54 protein encoded by the KISS1 gene. It retains the minimal active fragment required for agonist activity at the kisspeptin receptor (KISS1R, also known as GPR54), a G-protein coupled receptor expressed in hypothalamic GnRH neurons. In preclinical research environments, Kisspeptin-10 is utilized as a molecular probe to study the kisspeptin-GnRH signaling axis, which is a central regulatory node for gonadotropin-releasing hormone secretion. Experimental models examine its effects on LH and FSH pulsatility, pubertal onset mechanisms, and hypothalamic-pituitary-gonadal (HPG) axis regulation. Published laboratory studies describe the use of Kisspeptin-10 in in-vitro receptor binding assays, hypothalamic explant preparations, and in-vivo neuroendocrine challenge models across multiple species. Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ Molecular Formula: C₆₃H₈₃N₁₇O₁₄ Molecular Weight: 1302.46 g/mol For non-clinical laboratory research use only. Not for human consumption.