Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) designed for selective activation of the growth hormone secretagogue receptor (GHS-R1a). It is distinguished from earlier GHS compounds by its reported selectivity for GH release without significant stimulation of ACTH, cortisol, or prolactin in preclinical models. In laboratory experimental systems, Ipamorelin is used to investigate pulsatile growth hormone release kinetics, receptor-ligand interaction profiles, and the selectivity of somatotroph axis activation. Researchers employ the peptide in controlled in-vivo and in-vitro models to study dose-response dynamics, desensitization patterns, and feedback regulation within the GH-IGF-1 axis. Preclinical data describe Ipamorelin as exhibiting a favorable selectivity index compared to other GHS peptides, making it a useful tool for dissecting GH-specific signaling from broader neuroendocrine effects in experimental research. Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ Molecular Formula: C₃₈H₄₉N₉O₅ Molecular Weight: 711.86 g/mol CAS: 170851-70-4 Supplied exclusively for laboratory research use. Not for human consumption.